CFTR anticorps (AA 258-385) (CF®568)

N° du produit ABIN6174731

Détail du produit anti-CFTR anticorps (CF®568)

Antigène: CFTR (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))

Épitope: AA 258-385

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CFTR est conjugé à/à la CF®568

Application: Immunofluorescence (IF), Immunohistochemistry (IHC), Immunostaining (ISt)

Fonction: Mouse Monoclonal anti-CFTR CFTR/1785), CF568 Conjugate

Attributs du produit: This antibody recognizes a protein of 165-170 kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant human CFTR fragment (aa258-385) (exact sequence is proprietary)

Clone: CFTR-1785

Isotype: IgG2b

Information d'application

Indications d'application: Immunohistology (formalin) 1-2 μg/mL

• Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris, 1 mM EDTA  pH 9.0 for 10-20 min followed by cooling at RT for 20 min
• Immunofluorescence 0.5-1 μg/mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

MOLT-4 cells. Pancreas, Kidney or Placenta.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur CFTR

Antigène: CFTR (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR))

Autre désignation: CFTR (CFTR Produits)

Synonymes: anticorps ABC35, anticorps ABCC7, anticorps CF, anticorps CFTR/MRP, anticorps MRP7, anticorps TNR-CFTR, anticorps dJ760C5.1, anticorps CFTR, anticorps AW495489, anticorps Abcc7, anticorps RGD1561193, anticorps abc35, anticorps abcc7, anticorps cftr/mrp, anticorps mrp7, anticorps tnr-cftr, anticorps xcftr, anticorps si:dkey-270i2.2, anticorps cystic fibrosis transmembrane conductance regulator, anticorps cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7), anticorps CFTR, anticorps cftr-A, anticorps Cftr, anticorps cftr

Poids moléculaire: 165-170 kDa

ID gène: 1080

UniProt: P13569