PMEPA1 anticorps (Internal Region)
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- Antigène Voir toutes PMEPA1 Anticorps
- PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PMEPA1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- PMEPA1 Antibody detects endogenous levels of total PMEPA1.
- Homologie
- Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human PMEPA1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PMEPA1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))
- Autre désignation
- PMEPA1 (PMEPA1 Produits)
- Synonymes
- anticorps Tmepai, anticorps PMEPA1, anticorps TMEPAI, anticorps zgc:92731, anticorps tmepai, anticorps STAG1, anticorps 2210418I02Rik, anticorps AW455466, anticorps Erg1.2, anticorps N4wbp4, anticorps Stag1, anticorps prostate transmembrane protein, androgen induced 1, anticorps prostate transmembrane protein, androgen induced 1 L homeolog, anticorps Pmepa1, anticorps PMEPA1, anticorps pmepa1, anticorps pmepa1.L
- Sujet
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Description: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).
Gene: PMEPA1
- Poids moléculaire
- 37 kDa
- ID gène
- 56937
- UniProt
- Q969W9
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway
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