ABI1 anticorps (Internal Region)

N° du produit ABIN6259702

Détail du produit anti-ABI1 anticorps

Antigène: ABI1 (Abl-Interactor 1 (ABI1))

Épitope: Internal Region

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABI1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: Abi 1 Antibody detects endogenous levels of total Abi 1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Abi 1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ABI1

Antigène: ABI1 (Abl-Interactor 1 (ABI1))

Autre désignation: ABI1 (ABI1 Produits)

Synonymes: anticorps ABI-1, anticorps ABLBP4, anticorps E3B1, anticorps NAP1BP, anticorps SSH3BP, anticorps SSH3BP1, anticorps NAP1, anticorps Ssh3bp1, anticorps E3b1, anticorps abi1, anticorps wu:fc66g09, anticorps wu:fk56a10, anticorps zgc:73174, anticorps MGC84356, anticorps ABI1, anticorps abi-1, anticorps e3b1, anticorps nap1bp, anticorps ssh3bp, anticorps ssh3bp1, anticorps wu:fe48a10, anticorps zgc:153534, anticorps DKFZp469P1319, anticorps abl interactor 1, anticorps abl-interactor 1, anticorps abl-interactor 1a, anticorps abl interactor 1 S homeolog, anticorps abl-interactor 1b, anticorps Abl-interactor 1, anticorps Abl interactor 1, anticorps ABI1, anticorps Abi1, anticorps abi1a, anticorps abi1.S, anticorps abi1, anticorps abi1b, anticorps Bm1_44660, anticorps LOAG_04356

Sujet:

Description: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.

Gene: ABI1

Poids moléculaire: 55 kDa

ID gène: 10006

UniProt: Q8IZP0

Pathways: Signalisation RTK, Response to Water Deprivation, ER-Nucleus Signaling