ATP2A2 anticorps (Internal Region)

N° du produit ABIN6260121

Détail du produit anti-ATP2A2 anticorps

Antigène: ATP2A2 (ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATP2A2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: ATP2A2 Antibody detects endogenous levels of total ATP2A2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ATP2A2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ATP2A2

Antigène: ATP2A2 (ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2))

Autre désignation: ATP2A2 (ATP2A2 Produits)

Synonymes: anticorps atp2b, anticorps ca-p60a, anticorps dar, anticorps serca2, anticorps ATP2A2, anticorps ATP2B, anticorps DAR, anticorps DD, anticorps SERCA2, anticorps SERCA2A, anticorps ATP2, anticorps Serca2, anticorps SercaII, anticorps 9530097L16Rik, anticorps D5Wsu150e, anticorps SERCA2B, anticorps mKIAA4195, anticorps atp2a2, anticorps zgc:55380, anticorps ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 S homeolog, anticorps ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2, anticorps ATPase, Ca++ transporting, cardiac muscle, slow twitch 2, anticorps ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a, anticorps atp2a1.S, anticorps ATP2A2, anticorps Atp2a2, anticorps atp2a2a

Sujet:

Description: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca2+ signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity).

Gene: ATP2A2

Poids moléculaire: 115kDa

ID gène: 488

UniProt: P16615

Pathways: Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Ribonucleoside Biosynthetic Process