COPS7B anticorps (Internal Region)
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- Antigène Voir toutes COPS7B Anticorps
- COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))
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Épitope
- Internal Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp COPS7B est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- COPS7B Antibody detects endogenous levels of total COPS7B.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human COPS7B, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product COPS7B Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- COPS7B (COP9 Signalosome Complex Subunit 7b (COPS7B))
- Autre désignation
- COPS7B (COPS7B Produits)
- Synonymes
- anticorps MGC114836, anticorps D1Wsu66e, anticorps E130114M23, anticorps CSN7B, anticorps COP9 signalosome subunit 7B, anticorps COP9 signalosome subunit 7B S homeolog, anticorps Cops7b, anticorps COPS7B, anticorps cops7b.S
- Sujet
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Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Gene: COPS7B
- Poids moléculaire
- 30 kDa
- ID gène
- 64708
- UniProt
- Q9H9Q2
- Pathways
- Cycle Cellulaire
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