ERCC6 anticorps (Internal Region)

N° du produit ABIN6261592

Détail du produit anti-ERCC6 anticorps

Antigène: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: ERCC6 Antibody detects endogenous levels of total ERCC6.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ERCC6, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ERCC6

Antigène: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Autre désignation: ERCC6 (ERCC6 Produits)

Synonymes: anticorps ARMD5, anticorps CKN2, anticorps COFS, anticorps COFS1, anticorps CSB, anticorps RAD26, anticorps UVSS1, anticorps 4732403I04, anticorps C130058G22Rik, anticorps ercc6, anticorps Ercc6, anticorps ERCC excision repair 6, chromatin remodeling factor, anticorps excision repair cross-complementing rodent repair deficiency, complementation group 6, anticorps excision repair cross-complementation group 6, anticorps DNA excision repair protein ERCC-6, anticorps ERCC6, anticorps Ercc6, anticorps ercc6, anticorps LOC100719487

Sujet:

Description: Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.

Gene: ERCC6

Poids moléculaire: 168 kDa

ID gène: 2074

UniProt: Q03468

Pathways: Réparation de l'ADN, Chromatin Binding