HSPA2 anticorps

N° du produit ABIN6262410

Détail du produit anti-HSPA2 anticorps

Antigène: HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSPA2 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: HSPA2 Antibody detects endogenous levels of total HSPA2

Réactivité croisée: Humain

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human HSPA2

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur HSPA2

Antigène: HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))

Autre désignation: HSPA2 (HSPA2 Produits)

Synonymes: anticorps HSP70-2, anticorps HSP70-3, anticorps HSPA2, anticorps DKFZp468B217, anticorps 70kDa, anticorps HSP70.2, anticorps HSP70A2, anticorps Hsp70-2, anticorps Hspt70, anticorps Hst70, anticorps HSPA3, anticorps heat shock protein family A (Hsp70) member 2, anticorps heat shock protein Hsp20, anticorps heat shock 70kDa protein 2, anticorps heat shock protein 2, anticorps heat shock protein family A member 2, anticorps HSPA2, anticorps hspA2, anticorps Hspa2

Sujet:

Description: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).

Gene: HSPA2

Poids moléculaire: 70 kDa

ID gène: 3306

UniProt: P54652