IL1R2 anticorps (C-Term)

N° du produit ABIN6262549

Détail du produit anti-IL1R2 anticorps

Antigène: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL1R2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: IL1R2 Antibody detects endogenous levels of total IL1R2.

Homologie: Horse,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human IL1R2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur IL1R2

Antigène: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Autre désignation: IL1R2 (IL1R2 Produits)

Synonymes: anticorps CD121b, anticorps CDw121b, anticorps IL-1R-2, anticorps IL-1RT-2, anticorps IL-1RT2, anticorps IL1R2c, anticorps IL1RB, anticorps Il1r-2, anticorps IL-1R2, anticorps interleukin 1 receptor type 2, anticorps interleukin 1 receptor, type II, anticorps interleukin-like, anticorps IL1R2, anticorps Il1r2, anticorps KK34

Sujet:

Description: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Gene: IL1R2

Poids moléculaire: 45kDa

ID gène: 7850

UniProt: P27930

Pathways: Signalisation NF-kappaB