MIB1 anticorps

N° du produit ABIN6263248

Détail du produit anti-MIB1 anticorps

Antigène: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MIB1 est non-conjugé

Application: ELISA, Western Blotting (WB)

Specificité: MIB1 Antibody detects endogenous levels of total MIB1

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human MIB1

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur MIB1

Antigène: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Autre désignation: MIB1 (MIB1 Produits)

Synonymes: anticorps DIP-1, anticorps DIP1, anticorps LVNC7, anticorps MIB, anticorps ZZANK2, anticorps ZZZ6, anticorps E430019M12Rik, anticorps Mib, anticorps mKIAA1323, anticorps dip-1, anticorps mib, anticorps mindbomb, anticorps cg5841, anticorps chunp6889, anticorps fe47f05, anticorps im:7148100, anticorps mib1, anticorps wu:fe47f05, anticorps CG5841, anticorps D-mib, anticorps D-mib1, anticorps Dmel\CG5841, anticorps Dmib, anticorps MIB1, anticorps Mib1, anticorps dmib1, anticorps l(3)72CDa, anticorps l(3)72Db, anticorps mib1/2, anticorps mind-bomb, anticorps mindbomb E3 ubiquitin protein ligase 1, anticorps mindbomb E3 ubiquitin protein ligase 1 L homeolog, anticorps mind bomb 1, anticorps MIB1, anticorps Mib1, anticorps mib1.L, anticorps mib1

Sujet:

Description: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.

Gene: MIB1

Poids moléculaire: 110 kDa

ID gène: 57534

UniProt: Q86YT6

Pathways: SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2