PRNP anticorps (Internal Region)

N° du produit ABIN6264435

Détail du produit anti-PRNP anticorps

Antigène: PRNP (Prion Protein (PRNP))

Épitope: Internal Region

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRNP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: PRNP Antibody detects endogenous levels of total PRNP.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PRNP, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PRNP

Antigène: PRNP (Prion Protein (PRNP))

Autre désignation: PRNP (PRNP Produits)

Synonymes: anticorps ASCR, anticorps AltPrP, anticorps CD230, anticorps CJD, anticorps GSS, anticorps KURU, anticorps PRIP, anticorps PrP, anticorps PrP27-30, anticorps PrP33-35C, anticorps PrPc, anticorps p27-30, anticorps Prn, anticorps Prn-p, anticorps prp, anticorps cjd, anticorps prion, anticorps prp(c), anticorps MGC84114, anticorps PRP, anticorps PRPC, anticorps Prp, anticorps SIP, anticorps PRNP, anticorps AA960666, anticorps AI325101, anticorps PrP, anticorps PrPC, anticorps PrPSc, anticorps Prn-i, anticorps Sinc, anticorps prP27-30, anticorps prP33-35C, anticorps PrP-1, anticorps PrP1, anticorps prnprs1, anticorps stPrP-1, anticorps zgc:123004, anticorps prion protein, anticorps prion protein S homeolog, anticorps prion protein b, anticorps PRNP, anticorps Prnp, anticorps prnp.S, anticorps prnpb

Sujet:

Description: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

Gene: PRNP

Poids moléculaire: 27kDa

ID gène: 5621

UniProt: P04156

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation