RAB8A anticorps

N° du produit ABIN6264591

Détail du produit anti-RAB8A anticorps

Antigène: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAB8A est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: RAB8A Antibody detects endogenous levels of total RAB8A

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human RAB8A

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur RAB8A

Antigène: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Autre désignation: RAB8A (RAB8A Produits)

Synonymes: anticorps rab8A, anticorps DDBDRAFT_0206521, anticorps DDBDRAFT_0214885, anticorps DDB_0206521, anticorps DDB_0214885, anticorps HSH2D, anticorps mel, anticorps rab8, anticorps c-mel, anticorps MEL, anticorps RAB8, anticorps zgc:162699, anticorps AA409338, anticorps Mel, anticorps Rab8, anticorps rab8A protein, anticorps Rab GTPase, anticorps RAB8A, member RAS oncogene family, anticorps RAB8A, member RAS oncogene family S homeolog, anticorps rab8A, anticorps RAB8A, anticorps rab8a, anticorps rab8a.S, anticorps Rab8a

Sujet:

Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). Plays an important role in ciliogenesis (PubMed:21844891). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069).

Gene: RAB8A

Poids moléculaire: 24 kDa

ID gène: 4218

UniProt: P61006

Pathways: M Phase, Regulation of long-term Neuronal Synaptic Plasticity, SARS-CoV-2 Protein Interactome