RBPJ anticorps (C-Term)

N° du produit ABIN6264674

Détail du produit anti-RBPJ anticorps

Antigène: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RBPJ est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: RBPJ Antibody detects endogenous levels of total RBPJ.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human RBPJ, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur RBPJ

Antigène: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Autre désignation: RBPJ (RBPJ Produits)

Synonymes: anticorps AOS3, anticorps CBF1, anticorps IGKJRB, anticorps IGKJRB1, anticorps KBF2, anticorps RBP-J, anticorps RBPJK, anticorps RBPSUH, anticorps SUH, anticorps csl, anticorps AI843960, anticorps Igkjrb, anticorps Igkrsbp, anticorps RBP-J kappa, anticorps RBPjk, anticorps Rbpsuh, anticorps Su(H), anticorps XSu(H), anticorps xsu(h)1, anticorps Su(H)1, anticorps Su(h)A, anticorps ik:tdsubc_1e8, anticorps rbpj, anticorps rbpsuh, anticorps xx:tdsubc_1e8, anticorps Su(H)2, anticorps su(h)B, anticorps recombination signal binding protein for immunoglobulin kappa J region, anticorps recombination signal binding protein for immunoglobulin kappa J region S homeolog, anticorps recombination signal binding protein for immunoglobulin kappa J region a, anticorps recombination signal binding protein for immunoglobulin kappa J region b, anticorps RBPJ, anticorps Rbpj, anticorps rbpj.S, anticorps rbpja, anticorps rbpjb

Sujet:

Description: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4 % oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).

Gene: RBPJ

Poids moléculaire: 55kDa

ID gène: 3516

UniProt: Q06330

Pathways: Signalisation Notch, Stem Cell Maintenance, Smooth Muscle Cell Migration