VRK1 anticorps (Internal Region)
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- Antigène Voir toutes VRK1 Anticorps
- VRK1 (Vaccinia Related Kinase 1 (VRK1))
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Épitope
- Internal Region
- Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp VRK1 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- VRK1 Antibody detects endogenous levels of total VRK1.
- Homologie
- Pig,Bovine,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human VRK1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product VRK1 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- VRK1 (Vaccinia Related Kinase 1 (VRK1))
- Autre désignation
- VRK1 (VRK1 Produits)
- Synonymes
- anticorps vrk1, anticorps MGC64390, anticorps MGC75762, anticorps VRK1, anticorps PCH1, anticorps PCH1A, anticorps 51PK, anticorps wu:fe16f06, anticorps zgc:56266, anticorps vaccinia related kinase 1 L homeolog, anticorps vaccinia related kinase 1, anticorps Serine/threonine-protein kinase VRK1, anticorps vrk1.L, anticorps vrk1, anticorps VRK1, anticorps vrk-1, anticorps Vrk1
- Sujet
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Description: Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
Gene: VRK1
- Poids moléculaire
- 45 kDa
- ID gène
- 7443
- UniProt
- Q99986
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