XRCC3 anticorps (N-Term)
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- Antigène Voir toutes XRCC3 Anticorps
- XRCC3 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3))
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Épitope
- N-Term
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp XRCC3 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- XRCC3 Antibody detects endogenous levels of total XRCC3.
- Homologie
- Horse,Rabbit
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human XRCC3, corresponding to a region within N-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product XRCC3 Anticorps primaire
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- Indications d'application
- WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- XRCC3 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3))
- Autre désignation
- XRCC3 (XRCC3 Produits)
- Synonymes
- anticorps CMM6, anticorps 4432412E01Rik, anticorps AI182522, anticorps AW537713, anticorps MGC69118, anticorps im:7142103, anticorps zgc:101608, anticorps si:dkey-11b8.1, anticorps xrcc3, anticorps XRCC3, anticorps X-ray repair cross complementing 3, anticorps X-ray repair complementing defective repair in Chinese hamster cells 3, anticorps X-ray repair complementing defective repair in Chinese hamster cells 3 L homeolog, anticorps XRCC3, anticorps Xrcc3, anticorps xrcc3.L, anticorps xrcc3
- Sujet
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Description: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment, the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process, the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
Gene: XRCC3
- Poids moléculaire
- 38kDa
- ID gène
- 7517
- UniProt
- O43542
- Pathways
- Réparation de l'ADN
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