Cyclin D1 anticorps (AA 220-300)
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- Antigène Voir toutes Cyclin D1 (CCND1) Anticorps
- Cyclin D1 (CCND1)
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Épitope
- AA 220-300
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Cyclin D1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Fonction
- Cyclin D1 is a protein encoded by the CCND1 gene which is approximately 33,7 kDa. Cyclin D1 is localised to the nucleus and cytoplasm. It is involved in CDK-mediated phosphorylation and removal of Cdc6, cyclins and cell cycle regulation. This protein falls under the highly conserved cyclin family. It is a regulatory component of the cyclin D1-CDK4 complex that phosphorylates and inhibits members of the retinoblastoma protein family including RB1 and regulates the cell-cycle during G1/S transition. Cyclin D1 is expressed in the nervous system, liver, skin, intestine and lung. Mutations in the CCND1 gene may result in multiple myeloma. STJ92538 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cyclin D1 protein.
- Specificité
- Cyclin D1 Polyclonal Antibody detects endogenous levels of Cyclin D1 protein.
- Attributs du produit
- Rabbit polyclonal to Cyclin D1.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogène
- Synthesized peptide derived from human Cyclin D1 around the non-phosphorylation site of T286.
- Isotype
- IgG
- Top Product
- Discover our top product CCND1 Anticorps primaire
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- Indications d'application
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WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Antigène
- Cyclin D1 (CCND1)
- Autre désignation
- Cyclin D1 (CCND1 Produits)
- Synonymes
- anticorps BCL1, anticorps D11S287E, anticorps PRAD1, anticorps U21B31, anticorps AI327039, anticorps CycD1, anticorps Cyl-1, anticorps bcl-1, anticorps cD1, anticorps cb161, anticorps cycd1, anticorps etID37810.7, anticorps fb52e01, anticorps fc45c08, anticorps fc83a12, anticorps id:ibd1198, anticorps wu:fb52e01, anticorps wu:fc45c08, anticorps wu:fc83a12, anticorps ccnd1b, anticorps prad1, anticorps ccnd1, anticorps ccnd1a, anticorps bcl1, anticorps d11s287e, anticorps u21b31, anticorps CCND1, anticorps cyclin D1, anticorps cyclin D1 S homeolog, anticorps cyclin D1 L homeolog, anticorps CCND1, anticorps Ccnd1, anticorps ccnd1, anticorps ccnd1.S, anticorps ccnd1.L
- Poids moléculaire
- 36 kDa
- ID gène
- 595
- UniProt
- P24385
- Pathways
- Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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