PRKAA1 anticorps (AA 420-500)

N° du produit ABIN6283973

Détail du produit anti-PRKAA1 anticorps

Antigène: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Épitope: AA 420-500

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKAA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Fonction: AMPKα1 is a protein encoded by the PRKAA1 gene which is approximately 64 kDa. AMPKα1 is localised to the cytoplasm and nucleus. It is involved in RET signalling, mTOR signalling, AMP-activated protein kinase signalling, the regulation of TP53 activity and longevity regulating pathway. It is a catalytic subunit of AMP-activated protein kinase, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, it activates energy-producing pathways and inhibits energy-consuming processes such as protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPKα1 is expressed in the nervous system, liver, blood, intestine and kidney. Mutations in the PRKAA1 gene may result in obesity. STJ91580 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of AMPKα1 protein.

Specificité: AMPKα1 Polyclonal Antibody detects endogenous levels of AMPKα1 protein.

Attributs du produit: Rabbit polyclonal to AMPKα1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human AMPKalpha1 around the non-phosphorylation site of S496.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur PRKAA1

Antigène: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Autre désignation: AMPKalpha1 (PRKAA1 Produits)

Synonymes: anticorps AMPK, anticorps AMPKa1, anticorps cb116, anticorps im:7154392, anticorps sb:cb130, anticorps wu:fa94c10, anticorps AMPK1, anticorps AMPKalpha1, anticorps AI194361, anticorps AI450832, anticorps AL024255, anticorps C130083N04Rik, anticorps ampk, anticorps ampka1, anticorps PRKAA1, anticorps protein kinase AMP-activated catalytic subunit alpha 1, anticorps protein kinase, AMP-activated, alpha 1 catalytic subunit, anticorps protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog, anticorps PRKAA1, anticorps prkaa1, anticorps Prkaa1, anticorps prkaa1.L

Poids moléculaire: 65 kDa

ID gène: 5562

UniProt: Q13131

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg