CLEC7A anticorps

N° du produit ABIN641413

Détail du produit anti-CLEC7A anticorps

Antigène: CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CLEC7A est non-conjugé

Application: Flow Cytometry (FACS)

Fonction: Mouse Anti-Human Dectin-1

Specificité: 129-10231 recognizes human Dectin-1, also known as beta-glucan receptor (betaGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (betaGR-A and betaGR-B) and several minor isoforms. betaGR-A and betaGR-B differs by the presence and absence, respectively, of a stalk region. 129-10231 recognizes both of these isoforms. This antibody could be used to inhibit receptor function.

Purification: Purified

Immunogène: NIH3T3 cells expressing full length Beta-glucan receptor.

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry

Restrictions: For Research Use only

Stockage

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline pH7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Détails sur CLEC7A

Antigène: CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))

Autre désignation: Dectin-1 (CLEC7A Produits)

Synonymes: anticorps CLEC7A, anticorps BGR, anticorps Clecsf12, anticorps beta-GR, anticorps CANDF4, anticorps CLECSF12, anticorps DECTIN1, anticorps Clec7b, anticorps RGD1565140, anticorps C-type lectin domain containing 7A, anticorps C-type lectin domain family 7, member a, anticorps CLEC7A, anticorps Clec7a

Pathways: Activation of Innate immune Response