NGFR anticorps

N° du produit ABIN644003

Détail du produit anti-NGFR anticorps

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NGFR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Fonction: Rabbit Anti-Human CD271

Specificité: DS-PB-00434 recognises CD271, a transmembrane protein of 70-75kDa, otherwise known as Nerve Growth Factor Receptor (NGFR). It is a pro-apoptotic member of the tumor necrosis factor receptor (TNFR) family and its ligands include NGF, brain derived growth neurotrophic factor (BDNF), NT3 and NT4. CD271 has been shown to interact with tropomyosin-receptor-kinase A (TrkA) forming the high-affinity NGF receptor, while CD271 can signal alone, constituting the low-affinity NGF receptor. When signaling alone, CD271 is involved in apoptosis, neurite outgrowth during development and myelination. Mutations and changes in CD271 expression have been implicated in various pathological diseases including Alzheimer's Disease, cerebral oedema and retinoblastoma. Western BlotDetects a band of approximately 75-80kDa in A-20 cell lysate.

Réactivité croisée: Souris

Attributs du produit: Adhesion Molecule/Cell Surface

Purification: Purified

Immunogène: Antisera to CD271 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Isotype: IgG

Information d'application

Indications d'application: Immunohistology - Frozen, Western Blotting

Restrictions: For Research Use only

Stockage

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C

Références pour anticorps anti-NGFR (ABIN644003)

Frank, Schatton, Kim, Zhan, Wilson, Ma, Saab, Osherov, Widlund, Gasser, Waaga-Gasser, Kupper, Murphy, Frank: "VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth." dans: Cancer research, Vol. 71, Issue 4, pp. 1474-85, (2011) (PubMed).

Détails sur NGFR

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Autre désignation: CD271 (NGFR Produits)

Synonymes: anticorps ngfr, anticorps wu:fb38c02, anticorps wu:fc10h01, anticorps CD271, anticorps Gp80-LNGFR, anticorps TNFRSF16, anticorps p75(NTR), anticorps p75NTR, anticorps LNGFR, anticorps RNNGFRR, anticorps Tnfrsf16, anticorps p75, anticorps NRH1b, anticorps fullback, anticorps nrh1, anticorps p75ntr, anticorps tnfrsf16, anticorps p75NGFR, anticorps nerve growth factor receptor, anticorps neurotrophin receptor associated death domain, anticorps nerve growth factor receptor S homeolog, anticorps nerve growth factor receptor (TNFR superfamily, member 16), anticorps NGFR, anticorps nradd, anticorps Ngfr, anticorps ngfr.S

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding