PRKAR1A anticorps

N° du produit ABIN6566690

Détail du produit anti-PRKAR1A anticorps

Antigène: PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKAR1A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogène: Recombinant protein of human PRKAR1A

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PRKAR1A

Antigène: PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))

Autre désignation: PRKAR1A (PRKAR1A Produits)

Synonymes: anticorps ACRDYS1, anticorps ADOHR, anticorps CAR, anticorps CNC, anticorps CNC1, anticorps PKR1, anticorps PPNAD1, anticorps PRKAR1, anticorps TSE1, anticorps 1300018C22Rik, anticorps RIalpha, anticorps Tse-1, anticorps Tse1, anticorps RIIA, anticorps prkar1a, anticorps zgc:92515, anticorps im:7047729, anticorps cnc1, anticorps pkr1, anticorps ppnad1, anticorps prkar1, anticorps tse1, anticorps protein kinase cAMP-dependent type I regulatory subunit alpha, anticorps protein kinase, cAMP dependent regulatory, type I, alpha, anticorps protein kinase cAMP-dependent type 1 regulatory subunit alpha, anticorps protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a, anticorps cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene, anticorps protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog, anticorps PRKAR1A, anticorps Prkar1a, anticorps prkar1aa, anticorps LOC707275, anticorps prkar1a.S

Sujet:

Synonyms: ACRDYS1,ADOHR,cAMP dependent protein kinase regulatory subunit alpha 1,cAMP dependent protein kinase regulatory subunit RIalpha,cAMP dependent protein kinase type I alpha regulatory chain,cAMP dependent protein kinase type I alpha regulatory subunit,cAMP-dependent protein kinase type I-alpha regulatory subunit,CAR,Carney complex type 1,CNC 1,CNC,CNC1,DKFZp779L0468,KAP0,MGC17251,PKA RIA,PKR 1,PKR1,PPNAD 1,PPNAD1,PRKAR 1,PRKAR1,PRKAR1A,PRKAR1A/RARA FUSION GENE,Protein kinase A type 1a regulatory subunit,Protein kinase cAMP dependent regulatory type I alpha,PTC2 CHIMERIC ONCOGENE,INCLUDED,Tissue specific extinguisher 1,Tissue-specific extinguisher 1,TSE 1,TSE1

Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

Poids moléculaire:

Observed_MW: 45kDa

Calculated_MW: 38kDa/42kDa

ID gène: 5573

UniProt: P10644

Pathways: Signalisation Hedgehog, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma