PML anticorps

N° du produit ABIN5963926

Détail du produit anti-PML anticorps

Antigène: PML (Promyelocytic Leukemia (PML))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PML est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Affinity purification

Immunogène: Recombinant protein of human PML

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PML

Antigène: PML (Promyelocytic Leukemia (PML))

Autre désignation: PML (PML Produits)

Synonymes: anticorps MYL, anticorps PP8675, anticorps RNF71, anticorps TRIM19, anticorps 1200009E24Rik, anticorps AI661194, anticorps Trim19, anticorps RGD1562602, anticorps PML, anticorps promyelocytic leukemia, anticorps PML, anticorps Pml

Sujet:

Synonyms: Acure promyelocytic leukemia,inducer of,MYL,Pml,PML,PP8675,Probable transcription factor PML,Promyelocytic leukemia,Promyelocytic leukemia inducer of,Promyelocytic leukemia protein,Protein PML,RING finger protein 71,RNF 71,RNF71,TRIM 19,Tripartite motif protein TRIM19,Tripartite motif-containing protein 19

Background: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Poids moléculaire:

Observed_MW: 98kDa

Calculated_MW: 47-48kDa/62-97kDa

ID gène: 5371

UniProt: P29590

Pathways: Signalisation p53, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus