ORC1 anticorps

N° du produit ABIN6568465

Détail du produit anti-ORC1 anticorps

Antigène: ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ORC1 est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: Recombinant protein of human ORC1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ORC1

Antigène: ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))

Autre désignation: ORC1 (ORC1L Produits)

Synonymes: anticorps CG10667, anticorps DmORC1, anticorps DmOrc1, anticorps DmOrc1p, anticorps Dmel\\CG10667, anticorps ORC, anticorps ORC1, anticorps dORC1, anticorps orc1, anticorps rDmORC, anticorps ORC1L, anticorps HSORC1, anticorps PARC1, anticorps orc1l, anticorps xorc1, anticorps AA545195, anticorps MmORC1, anticorps Orc1l, anticorps Origin recognition complex subunit 1, anticorps origin recognition complex subunit 1, anticorps origin recognition complex subunit 1 L homeolog, anticorps origin recognition complex, subunit 1, anticorps Orc1, anticorps ORC1, anticorps orc1.L

Sujet:

Synonyms: HSORC1,MmORC1,orc1,ORC1,ORC1L,Origin Recognition Complex 1,Origin recognition complex subunit 1 (yeast homolog) like,Origin recognition complex subunit 1,Origin recognition complex subunit 1 homolog,Origin recognition complex subunit 1 like (S. cerevisia,Origin recognition complex subunit 1 like,Origin recognition complex subunit 1 S. cerevisiae homolog like ,Origin recognition complex,subunit 1 like (yeast),PARC1,Replication control protein 1

Background: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire:

Observed_MW: 90kDa

Calculated_MW: 97kDa

ID gène: 4998

UniProt: Q13415

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA