Presenilin 1 anticorps
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- Antigène Voir toutes Presenilin 1 (PSEN1) Anticorps
- Presenilin 1 (PSEN1)
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Presenilin 1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein of human PSEN1 (NP_015557.2).
- Isotype
- IgG
- Top Product
- Discover our top product PSEN1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000 IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- Presenilin 1 (PSEN1)
- Autre désignation
- PSEN1 (PSEN1 Produits)
- Synonymes
- anticorps pre1, anticorps psen, anticorps zfPS1, anticorps zf-PS1, anticorps ad3, anticorps fad, anticorps ps1, anticorps s182, anticorps X-PS-beta, anticorps X-PS-alpha, anticorps AD3, anticorps FAD, anticorps PS-1, anticorps PS1, anticorps S182, anticorps Ad3h, anticorps presenilin 1, anticorps presenilin 1 L homeolog, anticorps psen1, anticorps PSEN1, anticorps Psen1, anticorps psen1.L
- Sujet
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
- Poids moléculaire
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Observed_MW: 53kDa
Calculated_MW: 21kDa/42kDa/46kDa/48kDa/52kDa
- ID gène
- 5663
- UniProt
- P49768
- Pathways
- Signalisation Notch, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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