HLA-DPB1 anticorps (AA 77-105)

N° du produit ABIN657755

Détail du produit anti-HLA-DPB1 anticorps

Antigène: HLA-DPB1 (Major Histocompatibility Complex, Class II, DP beta 1 (HLA-DPB1))

Épitope: AA 77-105

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-DPB1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This HLA-DPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the Central region of human HLA-DPB1.

Clone: RB33626

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. WB: 1:4000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: HLA-DPB1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Détails sur HLA-DPB1

Antigène: HLA-DPB1 (Major Histocompatibility Complex, Class II, DP beta 1 (HLA-DPB1))

Autre désignation: HLA-DPB1 (HLA-DPB1 Produits)

Synonymes: anticorps PATR-DPB1, anticorps B-LB, anticorps B-LB2, anticorps B-LB21, anticorps BLB1, anticorps GSP-BLB1, anticorps DPB1, anticorps HLA-DP, anticorps HLA-DP1B, anticorps HLA-DPB, anticorps major histocompatibility complex, class II, DP beta 1, anticorps Major histocompatibility complex class II beta chain BLB1, anticorps PATR-DPB1, anticorps BLB1, anticorps HLA-DPB1

Sujet: HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Poids moléculaire: 29159

ID gène: 3115

NCBI Accession: NP_002112

UniProt: P04440

Pathways: TCR Signaling, Cancer Immune Checkpoints