ALK anticorps

N° du produit ABIN6654211

Détail du produit anti-ALK anticorps

Antigène: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp ALK est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Purified

Pureté: Protein A affinity

Immunogène: Recombinant full length human protein was used as the immunogen for this recombinant ALK antibody.

Clone: ALK1-2766R

Isotype: IgG kappa

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the recombinant ALK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (FFPE): 0.5-1 μg/mL for 30 min at RT

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant recombinant ALK antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur ALK

Antigène: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Autre désignation: ALK / Anaplastic Lymphoma Kinase (ALK Produits)

Synonymes: anticorps Tcrz, anticorps CD246, anticorps NBLST3, anticorps ALK, anticorps anaplastic lymphoma kinase, anticorps anaplastic lymphoma receptor tyrosine kinase, anticorps ALK receptor tyrosine kinase, anticorps Alk, anticorps ALK

Sujet: The wild-type anaplastic lymphoma kinase (ALK) protein is a 200 kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,  NPM-ALK, created by the t(2,5)(p23,q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80 kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5 % -10 % of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.

Pathways: Signalisation RTK