TNFRSF11A anticorps

N° du produit ABIN6655792

Détail du produit anti-TNFRSF11A anticorps

Antigène: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNFRSF11A est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Réactivité croisée: Humain, Souris

Purification: Anti-RANK Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-RANK from Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-RANK from other sources has not been determined.

Immunogène:

Immunogen: RANK Antibody was produced in mice prepared by repeated immunizations with a fusion protein containing internal amino acids from the human RANK protein.

Immunogen Type: Recombinant Protein

Clone: 9A725

Isotype: IgG1

Information d'application

Indications d'application:

Application Note: Anti-RANK Antibody is suitable for use in Flow (I), IHC (p) and WB. Expect a band approximately 90 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Flow Cytometry Dilution: 2-4 μg/mL

Western Blot Dilution: 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.05 % BSA

0.05 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Détails sur TNFRSF11A

Antigène: TNFRSF11A (Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A))

Autre désignation: RANK (TNFRSF11A Produits)

Synonymes: anticorps RANK, anticorps RGD1563614, anticorps TNFRSF11A, anticorps Ly109, anticorps ODFR, anticorps OFE, anticorps Rank, anticorps TRANCE-R, anticorps mRANK, anticorps CD265, anticorps FEO, anticorps LOH18CR1, anticorps OPTB7, anticorps OSTS, anticorps PDB2, anticorps TRANCER, anticorps TNF receptor superfamily member 11A, anticorps TNF receptor superfamily member 11a, anticorps tumor necrosis factor receptor superfamily, member 11a, NFKB activator, anticorps Tnfrsf11a, anticorps TNFRSF11A

Sujet:

Synonyms: RANK, Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor, ODFR, Receptor activator of NF-KB, CD265

Background: Anti-RANK Antibody detects human Rank. Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. RANK, or Receptor activator of NF-kB, TNF11aR, ODFR, CD265, is a member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2. Anti-RANK Antibody is ideal for investigators involved in apoptosis and NFkappaB research.

Gene Name: TNFRSF11A

ID gène: 8792

NCBI Accession: NP_003830

UniProt: Q9Y6Q6

Pathways: Signalisation NF-kappaB