SCN9A anticorps (C-Term)

N° du produit ABIN6656787

Détail du produit anti-SCN9A anticorps

Antigène: SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))

Épitope: C-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SCN9A est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: Anti-NAV1.7 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with NAV1.7 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against other Nav channels. Cross-reactivity with NAV1.7 from other sources has not been determined. Channels and Transporters research.

Immunogène:

Immunogen: Nav1.7 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to the cytoplasmic C-terminus region of human Nav1.7.

Immunogen Type: Recombinant Protein

Clone: S68-6

Isotype: IgG1

Information d'application

Indications d'application:

Immunohistochemistry Dilution: 0.1-1.0 μg/mL

Application Note: Anti-NAV1.7 Antibody is suitable for use in WB, IP, and IF microscopy. Expect a band approximately ~230 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1-10 μg/mL

IF Microscopy Dilution: 1.0-10 μg/mL

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

0.09 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Détails sur SCN9A

Antigène: SCN9A (Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A))

Autre désignation: NAV1.7 (SCN9A Produits)

Synonymes: anticorps SCN9A, anticorps DKFZp459G084, anticorps Nav1.7, anticorps PN1, anticorps mKIAA4197, anticorps Scn2a, anticorps ETHA, anticorps FEB3B, anticorps GEFSP7, anticorps NE-NA, anticorps NENA, anticorps SFNP, anticorps sodium channel, voltage-gated, type IX, alpha subunit, anticorps sodium voltage-gated channel alpha subunit 9, anticorps sodium channel protein type 9 subunit alpha, anticorps sodium channel, voltage-gated, type IX, alpha, anticorps SCN9A, anticorps LOC100016648, anticorps Scn9a

Sujet:

Synonyms: ETHA, hNE Na, NENA, PN1, SCN9A, voltage gated sodium channel subunit alpha Nav1.7, peripheral sodium channel 1, neuroendocrine sodium channel, Sodium channel protein type 9 subunit alpha

Background: Nav1.7 is a voltage-gated sodium channel and plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss of function of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system, blockers of Nav1.7 will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies, there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals.

Gene Name: Scn9a

ID gène: 6335

NCBI Accession: NP_002968

UniProt: Q15858