ROCK2 anticorps (AA 1001-1300) (Cy5.5)

N° du produit ABIN673364

Détail du produit anti-ROCK2 anticorps (Cy5.5)

Antigène: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Épitope: AA 1001-1300

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROCK2 est conjugé à/à la Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Homologie: Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ROCK2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ROCK2

Antigène: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Autre désignation: ROCK2 (ROCK2 Produits)

Synonymes: anticorps rocka-a, anticorps xROK, anticorps rock2, anticorps rok2, anticorps ROCK2, anticorps B230113H15Rik, anticorps ROKalpha, anticorps Rho-kinase, anticorps Rock-II, anticorps Rock2m, anticorps mKIAA0619, anticorps ROCK-II, anticorps ROK, anticorps Rho-associated, coiled-coil containing protein kinase 2 L homeolog, anticorps rho-associated, coiled-coil containing protein kinase 2a, anticorps Rho associated coiled-coil containing protein kinase 2, anticorps Rho-associated, coiled-coil containing protein kinase 2, anticorps Rho-associated coiled-coil containing protein kinase 2, anticorps rock2.L, anticorps rock2a, anticorps ROCK2, anticorps Rock2

Sujet:

Synonyms: ROCK-II, Rho-associated protein kinase 2, Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase 2, Rho-associated, coiled-coil-containing protein kinase II, p164 ROCK-2, ROCK2, KIAA619

Background: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP3, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p9RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

ID gène: 9475

UniProt: O75116

Pathways: Dynamique des Microtubules, Signalisation WNT, Tube Formation