TNFRSF18 anticorps
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- Antigène Voir toutes TNFRSF18 Anticorps
- TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
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Reactivité
- Souris
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Hôte
- Rat
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TNFRSF18 est non-conjugé
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Purification
- Purified by Protein A/G
- Immunogène
- Mouse CD25+ CD4+ T cells
- Clone
- DTA-1
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product TNFRSF18 Anticorps primaire
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- Indications d'application
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Positive Control: CD25+CD4+Tregs.
Known Application: Flow Cytometry (0.5-1 μg/million cells in 0.1ml), Immunofluorescence (0.5-1 μg/mL), Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-80 °C
- Stockage commentaire
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Date de péremption
- 24 months
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- Antigène
- TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
- Autre désignation
- GITR / Tnfrsf18 (TNFRSF18 Produits)
- Synonymes
- anticorps GITR, anticorps TNFRSF18, anticorps AITR, anticorps Gitr, anticorps CD357, anticorps GITR-D, anticorps TNF receptor superfamily member 18, anticorps tumor necrosis factor receptor superfamily, member 18, anticorps TNFRSF18, anticorps Tnfrsf18
- Sujet
- GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25+CD4+Tregs. In vivoactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
- Poids moléculaire
- 66-70kDa (Homodimer)
- ID gène
- 21936
- UniProt
- O35714
- Pathways
- Cancer Immune Checkpoints
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