DKC1 anticorps

N° du produit ABIN6943003

Détail du produit anti-DKC1 anticorps

Antigène: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp DKC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein within human DKC1 aa 300-450

Clone: 5C7

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur DKC1

Antigène: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Autre désignation: DKC1 (DKC1 Produits)

Synonymes: anticorps CBF5, anticorps DKC, anticorps DKCX, anticorps NAP57, anticorps NOLA4, anticorps XAP101, anticorps dyskerin, anticorps fv62a07, anticorps wu:fa28f10, anticorps wu:fc87a02, anticorps wu:fi24a05, anticorps wu:fv62a07, anticorps zgc:110395, anticorps DKC1, anticorps cbf5, anticorps dkc, anticorps nap57, anticorps nola4, anticorps xap101, anticorps BC068171, anticorps Nap57, anticorps AtCBF5, anticorps AtNAP57, anticorps homologue of NAP57, anticorps dyskerin pseudouridine synthase 1, anticorps microRNA 664b, anticorps dyskeratosis congenita 1, dyskerin, anticorps dyskeratosis congenita 1, dyskerin L homeolog, anticorps homologue of NAP57, anticorps DKC1, anticorps MIR664B, anticorps dkc1, anticorps dkc1.L, anticorps Dkc1, anticorps NAP57

Sujet:

Synonyms: H/ACA ribonucleoprotein complex subunit 4, CBF5 homolog, Dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoRNP protein DKC1, dyskerin pseudouridine synthase 1, NOLA4.

Background: Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells).

ID gène: 1736

UniProt: O60832

Pathways: Telomere Maintenance