DcR1 anticorps (Extracellular Domain)

N° du produit ABIN6990343

Détail du produit anti-DcR1 anticorps

Antigène: DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))

Épitope: AA 90-140, Extracellular Domain

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DcR1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: DcR1 Antibody is affinity chromatography purified via peptide column.

Immunogène: DcR1 antibody was raised against a peptide corresponding to amino acids in the extracellular domain of human DcR1 precursor. The immunogen is located within amino acids 90 - 140 of DcR1.

Isotype: IgG

Information d'application

Indications d'application: DcR1 antibody can be used for detection of DcR1 by Western blot at 1 μ,g/mL. An approximate 65 kDa band can be detected. Antibody can also be used for immunoflourescence starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human, mouse, and rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: DcR1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: DcR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur DcR1

Antigène: DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))

Autre désignation: DcR1 (TNFRSF10C Produits)

Synonymes: anticorps CD263, anticorps DCR1, anticorps DCR1-TNFR, anticorps LIT, anticorps TRAIL-R3, anticorps TRAILR3, anticorps TRID, anticorps TNFRSF10C, anticorps TNF receptor superfamily member 10c, anticorps TNFRSF10C

Sujet: DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

Poids moléculaire: 65 kDa

ID gène: 8794

UniProt: O14798

Pathways: Apoptose