NAIP anticorps (C-Term)

N° du produit ABIN6990465

Détail du produit anti-NAIP anticorps

Antigène: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Épitope: AA 1200-1250, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NAIP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: Minor, lower molecular weight bands may represent alternately spliced forms.

Purification: NAIP Antibody is affinity chromatography purified via peptide column.

Immunogène: NAIP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human NAIP. The immunogen is located within amino acids 1200 - 1250 of NAIP.

Isotype: IgG

Information d'application

Indications d'application: NAIP antibody can be used for the detection of NAIP by Western blot at 0.5 to 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NAIP Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NAIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur NAIP

Antigène: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Autre désignation: NAIP (NAIP Produits)

Synonymes: anticorps BIRC1, anticorps NLRB1, anticorps psiNAIP, anticorps AV364616, anticorps Birc1a, anticorps D13Lsd1, anticorps Naip, anticorps Naip-rs1, anticorps NLR family apoptosis inhibitory protein, anticorps NLR family, apoptosis inhibitory protein 1, anticorps NAIP, anticorps Naip1

Sujet: NAIP Antibody: Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR), these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules. Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.

Poids moléculaire: Predicted: 137, 154 kDa

Observed: 155 kDa

ID gène: 4671

UniProt: Q13075

Pathways: Apoptose, Inflammasome