SDHD anticorps (AA 30-80)

N° du produit ABIN6991691

Détail du produit anti-SDHD anticorps

Antigène: SDHD (Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD))

Épitope: AA 30-80

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SDHD est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: At least four isoforms of SDHD are known to exist, this antibody will detect the two longest isoforms.

Purification: SDHD Antibody is affinity chromatography purified via peptide column.

Immunogène: SDHD antibody was raised against a 15 amino acid synthetic peptide near the center of human SDHD. The immunogen is located within amino acids 30 - 80 of SDHD.

Isotype: IgG

Information d'application

Indications d'application: SDHD antibody can be used for detection of SDHD by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SDHD Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SDHD antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SDHD

Antigène: SDHD (Succinate Dehydrogenase Complex, Subunit D, Integral Membrane Protein (SDHD))

Autre désignation: SDHD (SDHD Produits)

Synonymes: anticorps RATSDHE1, anticorps SDH2, anticorps Sdh, anticorps Sdhe1, anticorps TDH, anticorps 3110001M13Rik, anticorps AVLL5809, anticorps C78570, anticorps PRO19626, anticorps CII-4, anticorps CII4, anticorps QPs3, anticorps cybS, anticorps CybS, anticorps CBT1, anticorps CWS3, anticorps PGL, anticorps PGL1, anticorps SDH4, anticorps MSN2.16, anticorps MSN2_16, anticorps succinate dehydrogenase 1-1, anticorps CybS-B, anticorps cbt1, anticorps pgl, anticorps pgl1, anticorps sdh4, anticorps cybS-B, anticorps sdhd, anticorps sdhda, anticorps zgc:100986, anticorps serine dehydratase, anticorps succinate dehydrogenase complex, subunit D, integral membrane protein, anticorps succinate dehydrogenase complex subunit D, anticorps succinate dehydrogenase 1-1, anticorps succinate dehydrogenase complex subunit D, integral membrane protein L homeolog, anticorps succinate dehydrogenase complex, subunit D, integral membrane protein b, anticorps Sds, anticorps Sdhd, anticorps SDHD, anticorps SDH1-1, anticorps sdhd.L, anticorps sdhdb

Sujet: SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.

ID gène: 9392

NCBI Accession: NP_002993

UniProt: O14521