WRNIP1 anticorps

N° du produit ABIN7004728

Détail du produit anti-WRNIP1 anticorps

Antigène: WRNIP1 (Werner Helicase Interacting Protein 1 (WRNIP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WRNIP1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of human WRNIP1

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:100, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.96 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur WRNIP1

Antigène: WRNIP1 (Werner Helicase Interacting Protein 1 (WRNIP1))

Autre désignation: WRNIP1 (WRNIP1 Produits)

Synonymes: anticorps WRNIP1, anticorps wrnip1, anticorps RP11-420G6.2, anticorps WHIP, anticorps bA420G6.2, anticorps zgc:85976, anticorps 4833444L21Rik, anticorps Wrnip, anticorps Whip, anticorps Werner helicase interacting protein 1, anticorps Werner helicase interacting protein 1 L homeolog, anticorps ATPase WRNIP1, anticorps WRNIP1, anticorps wrnip1.L, anticorps wrnip1, anticorps EDI_075920, anticorps CpipJ_CPIJ017857, anticorps PITG_07216, anticorps VDBG_02914, anticorps Wrnip1, anticorps PGTG_08805

Sujet: Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

UniProt: Q96S55