TRAIL anticorps

N° du produit ABIN7249904

Détail du produit anti-TRAIL anticorps

Antigène: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRAIL est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: KLH conjugated Synthetic peptide corresponding to Mouse Trail

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.94 mg/mL

Buffer: PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TRAIL

Antigène: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Autre désignation: TRAIL (TNFSF10 Produits)

Synonymes: anticorps APO2L, anticorps Apo-2L, anticorps CD253, anticorps TL2, anticorps TRAIL, anticorps A330042I21Rik, anticorps AI448571, anticorps APO-2L, anticorps Ly81, anticorps Trail, anticorps tl2, anticorps apo2l, anticorps cd253, anticorps trail, anticorps apo-2l, anticorps trail1, anticorps xtrail1, anticorps tnfsf10l2, anticorps zgc:92320, anticorps TNLG6A, anticorps TNF superfamily member 10, anticorps tumor necrosis factor (ligand) superfamily, member 10, anticorps tumor necrosis factor superfamily member 10, anticorps TNF superfamily member 10 S homeolog, anticorps TNFSF10, anticorps Tnfsf10, anticorps tnfsf10.S, anticorps tnfsf10

Sujet: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire:

Observed_MW: 33 kDa

Calculated_MW: 33 kDa

UniProt: P50591, P50592

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity