EGLN1 anticorps

N° du produit ABIN7255273

Détail du produit anti-EGLN1 anticorps

Antigène: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGLN1 est non-conjugé

Application: Immunohistochemistry (IHC)

Attributs du produit: Polyclonal Antibody

Purification: Affinity purification

Immunogène: A synthetic peptide of human EGLN1/EGLN2

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur EGLN1

Antigène: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Autre désignation: EGLN1/EGLN2 (EGLN1 Produits)

Synonymes: anticorps EGLN1, anticorps egln2, anticorps phd2, anticorps zgc:92314, anticorps AI503754, anticorps C1orf12, anticorps HIF-PH2, anticorps HPH-2, anticorps Hif-p4h-2, anticorps ORF13, anticorps Phd2, anticorps SM-20, anticorps PHD-2, anticorps PHD2, anticorps ECYT3, anticorps HIFPH2, anticorps HPH2, anticorps SM20, anticorps ZMYND6, anticorps egl nine homolog 1 (C. elegans), anticorps egl-9 family hypoxia inducible factor 1, anticorps egl-9 family hypoxia-inducible factor 1 S homeolog, anticorps egl-9 family hypoxia-inducible factor 1b, anticorps egl-9 family hypoxia-inducible factor 1, anticorps EGLN1, anticorps egln1.S, anticorps egln1b, anticorps Egln1

Sujet: The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]/The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B gene.

ID gène: 54583, 112398

UniProt: Q9GZT9, Q96KS0

Pathways: cAMP Metabolic Process, L'effet Warburg