ATF4 anticorps (AA 1-351)

N° du produit ABIN7111245

Cet anticorps anti-ATF4 est un anticorps Monoclonal produit chez le Souris, détectant ATF4 dans WB, IHC, ELISA et IF. Convient pour Humain et Souris.

Aperçu rapide pour ATF4 anticorps (AA 1-351) (ABIN7111245)

Antigène: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATF4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: 0B11

Détail du produit anti-ATF4 anticorps

Épitope: AA 1-351

Fonction: ATF4 antibody

Purification: Protein A+G purification

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène:

Immunogen sequence: 1-351aa

Immunogen: activating transcription factor 4

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:1000-1:2000, IHC: 1:50-1:300, IF: 1:20-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months

Date de péremption: 12 months

Détails sur ATF4

Antigène: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Autre désignation: ATF4

Sujet:

Synonyms: Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4)|Activating transcription factor 4|Cyclic AMP-responsive element-binding protein 2 (CREB-2, cAMP-responsive element-binding protein 2)|Tax-responsive enhancer element-binding protein 67 (TaxREB67)|ATF4|CREB2|TXREB

Background: Transcriptional activator. Binds the cAMP response element(CRE)(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production(By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase(ASNS) in response to endoplasmic reticulum(ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors(PubMed:26086088).

Poids moléculaire: 50-58 kDa

ID gène: 468

UniProt: P18848

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response