KIF7 anticorps

N° du produit ABIN7115710

Détail du produit anti-KIF7 anticorps

Antigène: KIF7 (Kinesin Family Member 7 (KIF7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIF7 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: kinesin family member 7

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000, IP: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur KIF7

Antigène: KIF7 (Kinesin Family Member 7 (KIF7))

Autre désignation: KIF7 (KIF7 Produits)

Synonymes: anticorps KIF7, anticorps DDBDRAFT_0204609, anticorps DDBDRAFT_0206583, anticorps DDB_0204609, anticorps DDB_0206583, anticorps ACLS, anticorps HLS2, anticorps JBTS12, anticorps UNQ340, anticorps cos2, anticorps costal2, anticorps kinesin family member 7, anticorps KIF7, anticorps kif7, anticorps Kif7

Sujet: Synonyms:KIF7, kinesin family member 7, Kinesin like protein KIF7, UNQ340 Background:Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog(Shh) and Indian hedgehog(Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and-independent mechanisms(PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes(By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation(By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development(By similarity).

Poids moléculaire: 150 kDa

ID gène: 374654

UniProt: Q2M1P5

Pathways: Signalisation Hedgehog