TNFAIP3 anticorps (AA 241-356)

N° du produit ABIN7127007

Détail du produit anti-TNFAIP3 anticorps

Antigène: TNFAIP3 (Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3))

Épitope: AA 241-356

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNFAIP3 est non-conjugé

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. HighA20expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa 241-356) of human TNFAIP3 protein (exact sequence is proprietary)

Isotype: IgG2

Information d'application

Indications d'application:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Hodgkin s Lymphoma or hepatocellular carcinoma (HCC).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur TNFAIP3

Antigène: TNFAIP3 (Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3))

Autre désignation: TNFAIP3 (TNFAIP3 Produits)

Synonymes: anticorps tnfaip3, anticorps MGC82339, anticorps TNFAIP3, anticorps A20, anticorps OTUD7C, anticorps TNFA1P2, anticorps Tnfip3, anticorps TNF alpha induced protein 3, anticorps TNF alpha induced protein 3 S homeolog, anticorps tumor necrosis factor, alpha-induced protein 3, anticorps TNFAIP3, anticorps tnfaip3.S, anticorps Tnfaip3

Sujet: A20, Putative DNA-binding protein A20, TNF alpha-induced protein 3 (TNFAIP3), Tumor Necrosis Factor alpha-Induced Protein 3(TNFAIP3), Zinc finger protein A20,A20 / TNFAIP3 (Marker of Tamoxifen Resistance)
Cellular localisation: Cytoplasmic, Cell Surface and Nuclear

Poids moléculaire: 90kDa

ID gène: 7128, 211600

UniProt: P21580

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Production of Molecular Mediator of Immune Response