Recombinant EPAS1 anticorps
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- Antigène Voir toutes EPAS1 Anticorps
- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
- Type d'anticorp
- Recombinant Antibody
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp EPAS1 est non-conjugé
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Application
- ELISA, Immunofluorescence (IF)
- Réactivité croisée
- Humain
- Purification
- Affinity-chromatography
- Immunogène
- A synthesized peptide derived from human HIF-2 alpha
- Clone
- 6A9
- Isotype
- IgG
- Top Product
- Discover our top product EPAS1 Anticorps primaire
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- Indications d'application
- Recommended dilution: IF:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
- Autre désignation
- EPAS1 (EPAS1 Produits)
- Synonymes
- anticorps EPAS1, anticorps ECYT4, anticorps HIF2A, anticorps HLF, anticorps MOP2, anticorps PASD2, anticorps bHLHe73, anticorps HIF-2alpha, anticorps HRF, anticorps Hif2a, anticorps bhlhe73, anticorps ecyt4, anticorps hif2, anticorps hif2a, anticorps hif2alpha, anticorps hlf, anticorps mop2, anticorps pasd2, anticorps EPAS, anticorps EPAS-1, anticorps endothelial PAS domain protein 1, anticorps endothelial PAS domain protein 1 L homeolog, anticorps EPAS1, anticorps epas1, anticorps Epas1, anticorps epas1.L
- Sujet
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Background: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Aliases: Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2), EPAS1, BHLHE73 HIF2A MOP2 PASD2
- UniProt
- Q99814
- Pathways
- Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg
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