FANCD2 anticorps (pSer222)

N° du produit ABIN7138489

Détail du produit anti-FANCD2 anticorps

Antigène: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Épitope: pSer222

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FANCD2 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of serine 222 (G-D-S(p)-Q-H) derived from Human FANCD2.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FANCD2

Antigène: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Autre désignation: FANCD2 (FANCD2 Produits)

Synonymes: anticorps FANCD2, anticorps CG17269, anticorps CG31192, anticorps CG31194, anticorps Dmel\\CG17269, anticorps dmFANCD2, anticorps xfancd2, anticorps FA-D2, anticorps FA4, anticorps FACD, anticorps FAD, anticorps FAD2, anticorps FANCD, anticorps 2410150O07Rik, anticorps AU015151, anticorps BB137857, anticorps Fanconi anemia complementation group D2, anticorps CG17269 gene product from transcript CG17269-RA, anticorps Fanconi anemia group D2 protein, anticorps Fanconi anemia, complementation group D2, anticorps Fanconi anemia complementation group D2 L homeolog, anticorps FANCD2, anticorps Fancd2, anticorps LOC100455970, anticorps fancd2, anticorps fancd2.L

Sujet:

Background:

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.

Ho GP, Margossian S, Taniguchi T, D'Andrea AD (2006)Mol Cell Biol 26, 7005-15. Nakanishi K, et al. (2002)Nat Cell Biol 4, 913-20. Taniguchi T, et al. (2002) Cell 109, 459-72 .

Aliases: DKFZp762A223 antibody, FA 4 antibody, FA D2 antibody, FA4 antibody, FAC D2 antibody, FACD 2 antibody, FACD antibody, FACD2 antibody, FACD2_HUMAN antibody, FAD antibody, FAD2 antibody, FANC D2 antibody, FANCD 2 antibody, FANCD antibody, FANCD2 antibody, FANCONI ANEMIA COMPLEMENTATION GROUP D antibody, Fanconi anemia complementation group D2 antibody, Fanconi anemia group D2 protein antibody, FANCONI PANCYTOPENIA TYPE 4 antibody, FLJ23826 antibody, OTTHUMP00000158853 antibody, OTTHUMP00000207925 antibody, Protein FACD2 antibody, Type 4 Fanconi pancytopenia antibody

UniProt: Q9BXW9

Pathways: Réparation de l'ADN