FOXO3 anticorps (pSer253)
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- Antigène Voir toutes FOXO3 Anticorps
- FOXO3 (Forkhead Box O3 (FOXO3))
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Épitope
- pSer253
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FOXO3 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogène
- Peptide sequence around phosphorylation site of serine 253(A-V-S(p)-M-D) derived from Human FKHRL1.
- Isotype
- IgG
- Top Product
- Discover our top product FOXO3 Anticorps primaire
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- Indications d'application
- WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- FOXO3 (Forkhead Box O3 (FOXO3))
- Autre désignation
- FOXO3 (FOXO3 Produits)
- Synonymes
- anticorps AF6q21, anticorps FKHRL1, anticorps FKHRL1P2, anticorps FOXO2, anticorps FOXO3A, anticorps zgc:92176, anticorps wu:fb50g02, anticorps wu:fi33f07, anticorps Fkhrl1, anticorps Foxo3a, anticorps FoxO3A, anticorps 1110048B16Rik, anticorps 2010203A17Rik, anticorps C76856, anticorps Fkhr2, anticorps FOXO-3, anticorps FOXO3, anticorps foxo3a, anticorps xfoxo3, anticorps foxO3, anticorps foxO, anticorps fkhr, anticorps foxo5, anticorps wu:fj65a12, anticorps zFkhr, anticorps forkhead box O3, anticorps forkhead box O3A, anticorps forkhead box O3 L homeolog, anticorps forkhead box O3b, anticorps FOXO3, anticorps foxo3a, anticorps Foxo3, anticorps foxo3.L, anticorps foxo3, anticorps foxO3, anticorps foxo3b
- Sujet
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Background:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Lehtinen M.K., Yuan Z., Boag P.R., Yang Y., Villen J., Becker E.B.E., DiBacco S., de la Iglesia N., Gygi S.P., Blackwell T.K., Bonni A.Cell 125:987-1001(2006) Morishita D., Katayama R., Sekimizu K., Tsuruo T., Fujita N.Cancer Res. 68:5076-5085(2008)Kress T.R., Cannell I.G., Brenkman A.B., Samans B., Gaestel M., Roepman P., Burgering B.M., Bushell M., Rosenwald A., Eilers M.Mol. Cell 41:445-457(2011)Aliases: AF6q21 antibody; AF6q21 protein antibody; DKFZp781A0677 antibody; FKHR2 antibody; FKHRL 1 antibody; FKHRL1 antibody; FKHRL1P2 antibody; Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1 antibody; Forkhead box O3 antibody; Forkhead box O3A antibody; Forkhead box protein O3 antibody; Forkhead box protein O3A antibody; Forkhead Drosophila homolog of in rhabdomyosarcoma like 1 antibody; Forkhead homolog (rhabdomyosarcoma) like 1 antibody; Forkhead in rhabdomyosarcoma like 1 antibody; Forkhead in rhabdomyosarcoma-like 1 antibody; FOX O3A antibody; FOXO2 antibody; foxo3 antibody; FOXO3_HUMAN antibody; FOXO3A antibody; MGC12739 antibody; MGC31925 antibody
- UniProt
- O43524
- Pathways
- Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis
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