PRKACA anticorps (pThr197)

N° du produit ABIN7138793

Cet anticorps Lapin Polyclonal détecte spécifiquement PRKACA dans WB, ELISA, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour PRKACA anticorps (pThr197) (ABIN7138793)

Antigène: PRKACA (Protein Kinase A, alpha (PRKACA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKACA est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-PRKACA anticorps

Épitope: pThr197

Fonction: Phospho-PRKACA (Thr197) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of threonine 197(R-T-W(p)-T-L) derived from Human PKA alpha/beta CAT.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PRKACA

Antigène: PRKACA (Protein Kinase A, alpha (PRKACA))

Autre désignation: PRKACA

Sujet:

Background: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Ghislaine Garrel, Endocrinology, Jun 1997, 138: 2259. W Li, Learn. Mem., Jan 1996, 2: 320 - 333. Sharmin Schauble, J. Biol. Chem., May 2007, 282: 14952 - 14959. Yong G. Wang, J. Gen. Physiol., Jan 1998, 111: 113.

Aliases: cAMP dependent protein kinase alpha catalytic subunit antibody, cAMP dependent protein kinase beta catalytic subunit antibody, cAMP dependent protein kinase catalytic beta subunit isoform 4ab antibody, cAMP dependent protein kinase catalytic subunit alpha antibody, cAMP dependent protein kinase catalytic subunit alpha, isoform 1 antibody, cAMP dependent protein kinase catalytic subunit beta antibody, cAMP-dependent protein kinase catalytic subunit alpha antibody, KAPCA_HUMAN antibody, PKA C alpha antibody, PKA C beta antibody, PKA C-alpha antibody, PKACA antibody, PKACB antibody, PPNAD4 antibody, PRKACA antibody, PRKACAA antibody, PRKACB antibody, Protein kinase A catalytic subunit alpha antibody, Protein kinase A catalytic subunit antibody, Protein kinase A catalytic subunit beta antibody, Protein kinase, cAMP dependent, catalytic, alpha antibody, Protein kinase, cAMP dependent, catalytic, beta antibody

UniProt: P17612

Pathways: Signalisation NF-kappaB, Signalisation Hedgehog, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2