FAK anticorps (pTyr925)

N° du produit ABIN7139087

Détail du produit anti-FAK anticorps

Antigène: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Épitope: pTyr925

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FAK est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain, Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogène: Peptide sequence around phosphorylation site of tyrosine 925 (K-V-Y(p)-E-N) derived from Human FAK.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:1000, IF:1:100-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FAK

Antigène: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Autre désignation: PTK2 (PTK2 Produits)

Synonymes: anticorps FADK, anticorps FAK, anticorps FAK1, anticorps FRNK, anticorps PPP1R71, anticorps p125FAK, anticorps pp125FAK, anticorps PTK2, anticorps Fadk, anticorps mKIAA4203, anticorps fak, anticorps fak1a, anticorps ptk2, anticorps ptk2a, anticorps wu:fa18c04, anticorps zgc:66114, anticorps CG10023, anticorps CT28129, anticorps DFAK, anticorps DFak, anticorps DFak56, anticorps Dfak, anticorps Dfak56, anticorps DmFAK, anticorps Dmel\\CG10023, anticorps Fak56, anticorps Fak56D, anticorps fak56, anticorps protein tyrosine kinase 2, anticorps protein tyrosine kinase 2 L homeolog, anticorps PTK2 protein tyrosine kinase 2, anticorps protein tyrosine kinase 2ab, anticorps Focal adhesion kinase, anticorps PTK2, anticorps ptk2.L, anticorps Ptk2, anticorps ptk2ab, anticorps Fak

Sujet:

Background: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Sanders MA, et al. (2005) J Biol Chem, 280(25): 23516-22.
Cherubini A, et al. (2005) Mol Biol Cell, 16(6): 2972-83.
Toriumi Y, et al. (2003) FEBS Lett, 553(3): 419-22.

Aliases: FADK 1 antibody, FADK antibody, FAK related non kinase polypeptide antibody, FAK1 antibody, FAK1_HUMAN antibody, Focal adhesion kinase 1 antibody, Focal adhesion Kinase antibody, Focal adhesion kinase isoform FAK Del33 antibody, Focal adhesion kinase related nonkinase antibody, FRNK antibody, p125FAK antibody, pp125FAK antibody, PPP1R71 antibody, Protein phosphatase 1 regulatory subunit 71 antibody, Protein tyrosine kinase 2 antibody, Protein-tyrosine kinase 2 antibody, Ptk2 antibody, PTK2 protein tyrosine kinase 2 antibody

UniProt: Q05397

Pathways: Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling