The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK11 is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
Synonyms: MAPK11phospho T180/Y182, Human p38Beta MAP kinase mRNA complete cds, MAP kinase 11, MAP kinase p38 beta, MAPK 11, Mapk11, Mitogen activated protein kinase 11, Mitogen activated protein kinase p38 2, Mitogen activated protein kinase p38 beta, mitogen-activated protein kinase 11, Mitogen-activated protein kinase p38 beta, MK11_HUMAN, p38 2, p38-2, P38B, p38Beta, P38BETA2, PRKM11, protein kinase mitogen activated 11, SAPK2, SAPK2B, Stress activated protein kinase 2, Stress-activated protein kinase 2.