PIK3R2 anticorps (Regulatory Subunit beta)
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- Antigène Voir toutes PIK3R2 (PI3K p85b) Anticorps
- PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))
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Épitope
- AA 75-125, Regulatory Subunit beta
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PIK3R2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit beta protein (75-125AA)
- Isotype
- IgG
- Top Product
- Discover our top product PI3K p85b Anticorps primaire
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- Indications d'application
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- PIK3R2 (PI3K p85b) (Phosphoinositide 3 Kinase, p85 beta (PI3K p85b))
- Autre désignation
- PIK3R2 (PI3K p85b Produits)
- Synonymes
- anticorps MPPH, anticorps P85B, anticorps p85, anticorps p85-BETA, anticorps pik3r2, anticorps MGC80449, anticorps p85beta, anticorps phosphoinositide-3-kinase regulatory subunit 2, anticorps phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta), anticorps phosphoinositide-3-kinase, regulatory subunit 2 (beta), anticorps PIK3R2, anticorps pik3r2, anticorps Pik3r2
- Sujet
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Background: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
Aliases: p85 antibody, p85 beta antibody, P85B antibody, P85B_HUMAN antibody, Phosphatidylinositol 3 kinase antibody, Phosphatidylinositol 3 kinase regulatory beta subunit antibody, Phosphatidylinositol 3 kinase regulatory subunit beta antibody, Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2 antibody, Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta) antibody, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta antibody, Phosphatidylinositol 3-kinase regulatory subunit beta antibody, Phosphoinositide 3 kinase regulatory subunit 2 (beta) antibody, Phosphoinositide 3 kinase regulatory subunit 2 antibody, Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta) antibody, Phosphoinositide 3 kinase regulatory subunit polypeptide 2 antibody, Phosphoinositide 3 kinase, regulatory subunit 2 (beta) antibody, Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta) antibody, PI3 kinase p85 beta subunit antibody, PI3 kinase p85 subunit beta antibody, PI3-kinase regulatory subunit beta antibody, PI3-kinase subunit p85-beta antibody, PI3K antibody, PI3K regulatory subunit beta antibody, PIK3R 2 antibody, PIK3R2 antibody, PtdIns 3 kinase p85 beta antibody, PtdIns-3-kinase regulatory subunit beta antibody, PtdIns-3-kinase regulatory subunit p85-beta antibody
- UniProt
- O00459
- Pathways
- VEGF Signaling, BCR Signaling
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