LAMTOR1 anticorps (AA 2-161)

N° du produit ABIN7167068

Détail du produit anti-LAMTOR1 anticorps

Antigène: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Épitope: AA 2-161

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAMTOR1 est non-conjugé

Application: Immunofluorescence (IF), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ragulator complex protein LAMTOR1 protein (2-161AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000, IF:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LAMTOR1

Antigène: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Autre désignation: LAMTOR1 (LAMTOR1 Produits)

Synonymes: anticorps C11orf59, anticorps PDRO, anticorps Ragulator1, anticorps p18, anticorps p27RF-Rho, anticorps 2400001E08Rik, anticorps Pdro, anticorps C15H11orf59, anticorps c11orf59, anticorps flj20625, anticorps p27rf-rho, anticorps pdro, anticorps ragulator1, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 1, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 S homeolog, anticorps LAMTOR1, anticorps Lamtor1, anticorps lamtor1.S

Sujet:

Background: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

Aliases: C11orf59 antibody, LAMTOR1 antibody, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 antibody, Lipid raft adaptor protein p18 antibody, LTOR1_HUMAN antibody, p18 antibody, p27Kip1-releasing factor from RhoA antibody, p27RF-Rho antibody, PDRO antibody, PP7157 antibody, Protein associated with DRMs and endosomes antibody, Ragulator complex protein LAMTOR1 antibody, ragulator complex protein PDRO antibody, Ragulator1 antibody, RhoA activator C11orf59 antibody

UniProt: Q6IAA8