LAMTOR1 anticorps (AA 111-161)

N° du produit ABIN7452946

Détail du produit anti-LAMTOR1 anticorps

Antigène: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Épitope: AA 111-161

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAMTOR1 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit anti-LAMTOR1 Antibody, Affinity Purified

Homologie: Mouse,Rat,Bovine,Orangutan

Purification: Affinity Purified

Immunogène: Between AA 111 and 161

Isotype: IgG

Information d'application

Indications d'application:

IP: Not recommended

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur LAMTOR1

Antigène: LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))

Autre désignation: LAMTOR1 (LAMTOR1 Produits)

Synonymes: anticorps C11orf59, anticorps PDRO, anticorps Ragulator1, anticorps p18, anticorps p27RF-Rho, anticorps 2400001E08Rik, anticorps Pdro, anticorps C15H11orf59, anticorps c11orf59, anticorps flj20625, anticorps p27rf-rho, anticorps pdro, anticorps ragulator1, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 1, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 S homeolog, anticorps LAMTOR1, anticorps Lamtor1, anticorps lamtor1.S

Sujet: Background: As part of the Ragulator complex, LAMTOR1 is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. LAMTOR1 is activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. It is also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. It may also play a role in RHOA activation [taken from the Universal Protein Resource (UniProt) Q6IAA8].

ID gène: 55004

UniProt: Q6IAA8