PRKACA anticorps

N° du produit ABIN7269625

Cet anticorps Souris Monoclonal détecte spécifiquement PRKACA dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour PRKACA anticorps (ABIN7269625)

Antigène: PRKACA (Protein Kinase A, alpha (PRKACA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRKACA est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-PRKACA anticorps

Fonction: PKA C-alpha (PRKACA) Mouse mAb

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant protein of human PKA C-alpha (PKA C-alpha (PRKACA)).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PRKACA

Antigène: PRKACA (Protein Kinase A, alpha (PRKACA))

Autre désignation: PRKACA

Sujet: This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.,PRKACA, PKACA, PPNAD4, cAMP-dependent protein kinase catalytic subunit alpha,AMPK Signaling Pathway,Apoptosis,Apoptosis_Inhibition of Apoptosis,Apoptosis_Mitochondrial Control of Apoptosis,Cancer,Carbohydrate metabolism,Cell Biology & Developmental Biology,Cell Cycle,Cell Cycle_Centrosome,Cytoskeleton,Cytoskeleton_Actins,Cytoskeleton_Microtubules,Endocrine & Metabolism,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,Hedgehog Signaling Pathway,Immunology & Inflammation,Insulin Receptor Signaling Pathway,Kinase,Kinase_Serine/threonine kinases,Lipid Metabolism,MAPK-Erk Signaling Pathway,Neurodegenerative Diseases,Neurodegenerative Diseases_Dopamine Signaling in Parkinsons Disease,Neuroscience,NF-kB Signaling Pathway,Protein phosphorylation,Signal Transduction,PRKACA

Poids moléculaire: 39kDa/40kDa

ID gène: 5566

UniProt: P17612

Pathways: Signalisation NF-kappaB, Signalisation Hedgehog, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interactome, Phosphorylation & l'infection par le SRAS-CoV-2