PSMC4 anticorps (AA 368-418)

N° du produit ABIN7454974

Détail du produit anti-PSMC4 anticorps

Antigène: PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))

Épitope: AA 368-418

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSMC4 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-PSMC4 Antibody, Affinity Purified

Homologie: Mouse,Rat,Bovine

Purification: Affinity Purified

Immunogène: Between AA 368 and 418

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur PSMC4

Antigène: PSMC4 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 4 (PSMC4))

Autre désignation: PSMC4 (PSMC4 Produits)

Synonymes: anticorps NCU02260.1, anticorps AO090003000692, anticorps DDBDRAFT_0188209, anticorps DDBDRAFT_0191435, anticorps DDB_0188209, anticorps DDB_0191435, anticorps MIP224, anticorps RPT3, anticorps S6, anticorps TBP-7, anticorps TBP7, anticorps CIP21, anticorps Tbp7, anticorps 26S protease regulatory subunit 6B, anticorps regulatory particle, ATPase-like-3, anticorps 26S proteasome regulatory subunit 6B, anticorps proteasome 26S subunit, ATPase 4, anticorps proteasome (prosome, macropain) 26S subunit, ATPase, 4, anticorps LOC732870, anticorps rpt-3, anticorps ATEG_04674, anticorps LELG_01296, anticorps HCAG_00039, anticorps LOC5568998, anticorps GL50803_7950, anticorps EDI_044950, anticorps AOR_1_1218154, anticorps PTRG_03339, anticorps psmC4, anticorps prs6b, anticorps LOC100381342, anticorps psmc4, anticorps PSMC4, anticorps Psmc4

Sujet: Background: PSMC4 [proteasome (prosome, macropain) 26S subunit, ATPase, 4] is a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMC4 interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1 [taken from NCBI Entrez Gene (Gene ID: 5704)].

ID gène: 5704

NCBI Accession: NP_006494

UniProt: P43686

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway