BRCA1 anticorps (pSer1189) (Cy5.5)

N° du produit ABIN756642

Détail du produit anti-BRCA1 anticorps (Cy5.5)

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Épitope: pSer1189

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCA1 est conjugé à/à la Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human BRCA1 around the phosphorylation site of Ser1189

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur BRCA1

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Autre désignation: BRCA1 (BRCA1 Produits)

Synonymes: anticorps BRCAI, anticorps BRCC1, anticorps BROVCA1, anticorps IRIS, anticorps PNCA4, anticorps PPP1R53, anticorps PSCP, anticorps RNF53, anticorps iris, anticorps pscp, anticorps brcai, anticorps brcc1, anticorps rnf53, anticorps brca1, anticorps BRCA1, anticorps LOC100224649, anticorps BRCA1, DNA repair associated, anticorps breast cancer 1, anticorps breast cancer 1, early onset, anticorps breast cancer 1 L homeolog, anticorps BRCA1, anticorps brca1, anticorps LOC755086, anticorps Brca1, anticorps brca1.L

Sujet:

Synonyms: BRCA1 phospho Ser1189, BRCA1 phospho S1189, p-BRCA1 phospho S1189, BRCA 1, BRCA1, BRCA1/BRCA2 containing complex subunit 1, BRCA1/BRCA2-containing complex, subunit 1, BRCA1_HUMAN, BRCAI, BRAC 1, BRCA 1, BRCC 1, BRCC1, Breast Cancer 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, Breast and ovarian cancer susceptibility protein 1, Breast Ovarian Cancer Susceptibility, IRIS, Papillary Serous Carcinoma Of The Peritoneum, PSCP, RING finger protein 53, BROVCA1, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, RNF53, BAP1.

Background: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].

ID gène: 672

Pathways: Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus